WebMar 27, 2024 · These results show that Pak5 shuttles from mitochondria to the nucleus and that the mitochondrial localization of Pak5 is vital to its effects on cell survival. We thank Connie Cepko for the C17.2 cell line, Sandy Jablonski (Cell Imaging Core Facility) for assistance, and Peter Adams and Maureen Murphy for reviewing the manuscript. WebJun 18, 2024 · Huntington’s disease (HD) is a multi-system disorder that is caused by expanded CAG repeats within the exon-1 of the huntingtin (HTT) gene that translate to the polyglutamine stretch in the HTT protein. HTT interacts with the proteins involved in gene transcription, endocytosis, and metabolism. HTT may also directly or indirectly affect …
IJMS Free Full-Text Purine Nucleotides Metabolism and …
WebFeb 1, 2024 · The nuclear pore is responsible for regulating the transport of proteins from the cytoplasm into the cell nucleus and for ushering RNA out of it. It works like a … WebDec 17, 2003 · Despite their spatial and functional differences in the nucleus, our results from transfection experiments show that both isoforms can shuttle into the cytoplasm and both are found to be associated with functional polysomes. This result seems contradictory to the proposed different functions for the two isoforms. small campers with lots of windows
Hop-on hop-off: importin-α-guided tours to the nucleus in innate …
WebJan 1, 2001 · Another nuclear protein involved in splicing, hnRNP A1, although localized primarily in the nucleoplasm, shuttles continuously between the nucleus and the cytoplasm ( Piñol-Roma and Dreyfuss 1991, 1992; Weighardt et al. 1995 ). Among the superfamily of hnRNP proteins, it was found that not only hnRNP A1, but also A2, D, E, I, and K shuttle ... WebMay 5, 2024 · Drosophila oocytes develop together with 15 sister germline nurse cells (NCs), which pass products to the oocyte through intercellular bridges. The NCs are completely … WebNucleus Volume 1 Issue 3. pim1 /RanGEF mutant phenotype might . be caused by the failure to transport Ran targets into the nucleus. We have investi-gated Alp7 as a potential Ran … small campers with dual axles for sale