Phenytoin definition
WebDefinition. Phenytoin (diphenylhydantoin; Dilantin) is a nonsedating anticonvulsant agent that is effective against generalized tonic‐clonic and partial complex seizures. It has also been used as an antidysrhythmic drug. Web11. aug 2024 · Phenytoin is an antiepileptic drug with a narrow therapeutic index and large interpatient pharmacokinetic variability, partly due to genetic variation in CYP2C9.Furthermore, the variant allele HLA-B*15:02 is associated with an increased risk of Stevens–Johnson syndrome and toxic epidermal necrolysis in response to phenytoin …
Phenytoin definition
Did you know?
WebPhenytoin /fəˈnɪtoʊɨn/ is a hydantoin-derivative anticonvulsant drug used primarily in the management of complex partial seizures and generalized tonic-clonic seizures. Phenytoin is also used to prevent seizures following neurosurgery. Phenytoin is believed to protect against seizures by causing voltage-dependent block of voltage-gated sodium channels. Web2. máj 2024 · Phenytoin is an anti-epileptic drug, also called an anticonvulsant. Phenytoin works by slowing down impulses in the brain that cause seizures. Phenytoin is used to control seizures. It does not treat all types of seizures, and your doctor will determine if it … Phenytoin Breastfeeding Warnings. Benefit should outweigh risk Excreted into … Phenytoin Interactions. There are 813 drugs known to interact with phenytoin, along … Phenytoin metabolism is slightly decreased in elderly patients. Therapeutic Drug … Applies to phenytoin: oral capsule extended release, oral suspension, oral tablet … Drugs.com provides accurate and independent information on more than … Phenytoin is primarily metabolized by the hepatic cytochrome P450 enzyme …
Web3. feb 2024 · phenytoin ). Anticonvulsants are also used for pain management (e.g., carbamazepine or gabapentin ) and as mood stabilizers in bipolar disorders ( valproate ). For more information on the treatment of generalized seizures , see treatment of epileptic seizures. Overview WebPhenytoin (Dilantin) Correction for Albumin / Renal Failure Corrects serum phenytoin level for renal failure and/or hypoalbuminemia. INSTRUCTIONS Use in patients with albumin ≤3.2 g/dL (32 g/L). The “Sheiner-Tozer Equation” is the official name of this correction.
Web1. apr 1994 · Phenytoin: Phenytoin exhibits marked saturation of metabolism at concentrations in the therapeutic range (10-20 mg/L) (Fig. 2). Consequently, small increases in dose result in large increases in total and unbound steady state drug concentration. WebHypocalcemia is a condition where you have low calcium levels in your blood. It can be an inherited disorder or it can be caused by other conditions. Calcium is a critical mineral for your bone and...
Web2. jún 2024 · Phenytoin is used as both an abortive and preventive medication in seizure management. [ 1, 2, 3] The total phenytoin reference range varies by age, as follows: Children and adults: 10-20 µg/mL... flyback animeWeb1. sep 2013 · Therapeutic drug monitoring of phenytoin is carried out to ensure effective and safe levels. Some of the factors complicating phenytoin dosing include a narrow therapeutic window, high degree of protein binding, and nonlinear pharmacokinetics. However, serum drug levels should only be taken when there is a clear indication to guide patient ... greenhouse fittings screwfixWebPhénytoïne : Mécanisme d'action. La phénytoïne est un anticonvulsivant. Elle diminue l'automatisme sans altérer la vitesse de conduction. Elle raccourcit les périodes réfractaires. Les effets antiépileptiques de la phénytoïne sont probablement dus aux mécanismes cellulaires suivants : modulation des canaux sodiques voltage ... flyback apfcWeb24. aug 2024 · h Inhibitor of P-gp (, defined as those increasing AUC or Cmax of digoxin, dabigatran, or edoxaban ≥1.5-fold). i Strong inhibitor of CYP3A4 and weak inducer of CYP2B6, CYP2C9, and CYP2C19. j... greenhouse fixing boltsWebPhenytoin, one of the older antiepileptic drugs can result in an occasionally symptomatic, axonal, sensorimotor neuropathy which improves after withdrawal. From the Cambridge English Corpus These examples are from corpora and from sources on the web. flyback active clampWebII. Defining Hazardous Drugs Hazardous drugs include those used for cancer che - motherapy, antiviral drugs, hormones, some bio-engineered drugs, and other miscellaneous drugs. The NIOSH definition of hazardous drugs used in the Alert is based on a definition originally devel-oped in 1990 by the American Society of Hospital greenhouse flagstaff promo codeWebPhenytoin is used to control certain type of seizures, and to treat and prevent seizures that may begin during or after surgery to the brain or nervous system. Phenytoin is in a class of medications called anticonvulsants. It works by decreasing abnormal … greenhouse fixings and fittings