How does daptomycin cause myopathy

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August undefined, 2024

WebDec 19, 2024 · In this retrospective, case-control study, both myopathy and rhabdomyolysis were increased by coadministration. Daptomycin has been associated with clinical myopathy in 2% to 14% of patients. Similarly, statins are associated with myopathy in 5% to 10% of patients. Although prior reports suggested no increased risk for myopathy when … WebDaptomycin has excellent coverage against gram-positive bacteria. The adverse effect profile has included rare reports of myopathy and elevated CK levels. Daptomycin is a …

Daptomycin (Intravenous Route) Before Using - Mayo Clinic

WebAn endocrine myopathy is a myopathy caused by issues with the endocrine system, which controls hormone production. Endocrine myopathies can be caused by thyroid or adrenal diseases. Infectious... WebDec 11, 2024 · Daptomycin is associated with an increased incidence of myopathy and rhabdomyolysis. There have been cases reported in patients with and without acute renal … cte of sio2

Daptomycin (Intravenous Route) - Mayo Clinic - Mayo Clinic

WebIn terms of adverse reactions, daptomycin is known to cause elevations in creatine kinase and myopathy, though this rarely leads to rhabdomyolysis, additionally, long-term use may cause allergic pneumonitis (Beauduy & Winston, 2024a; Macdougall, 2024b ). View chapter Purchase book Recommended publications Essentials of Neuroanesthesia Book • 2024 WebMar 1, 2024 · This medicine may cause a kidney problem called tubulointerstitial nephritis. Check with your doctor right away if you have a bloody or cloudy urine, fever, skin rash, … http://neuromuscular.wustl.edu/mother/myotox.htm cte of titanium 6al 4v

Daptomycin Injection: MedlinePlus Drug Information

Daptomycin - Infectious Diseases - MSD Manual Professional Edition

WebMar 21, 2024 · Bloating or swelling of the face, arms, hands, lower legs, or feet fever tingling of the hands or feet unusual weight gain or loss Less common Agitation black, tarry … WebDaptomycin. Daptomycin is a lipopeptide that targets bacterial cell membranes and has been successfully used to treat skin and soft tissue infections caused by Gram-positive bacteria, including E. faecalis species. ... The primary toxicity seen is a dose-dependent, reversible myopathy that can be monitored by elevation in serum creatinine ... cte of solderWebDoses more than 8 mg/kg IV every 24 hours increase the risk of CPK elevations and myopathy. Use clinical judgment and frequent monitoring if pursuing doses of 10 to 12 mg/kg IV every 24 hours in patients receiving an UFR of at least 3 L/hour. Pediatric patients†. 8 mg/kg/dose IV every 48 hours. Hybrid hemodialysis†. cte of soda lime glass

"WebComment: Coadministration of daptomycin with HMG-CoA reductase inhibitors may increase CPK levels and risk for myopathy; consider temporary suspension of HMG-CoA … " - How does daptomycin cause myopathy

How does daptomycin cause myopathy

Myopathies: Types, Causes, Diagnosis, and Treatment - WebMD

WebMar 1, 2024 · irregular breathing. irregular heartbeat. irritability. itching in the genital or other skin areas. itching, pain, redness, swelling, tenderness, or warmth on the skin. … WebMar 1, 2024 · Daptomycin injection is used to treat complicated skin and skin structure infections (cSSSI). It is also used to treat infections in the bloodstream (bacteremia), including right-sided infective endocarditis. Daptomycin belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth.

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WebNov 24, 2024 · It is less nephrotoxic than vancomycin. It has a unique bactericidal mechanism through destruction of bacterial membrane potential. However, one of the … WebMar 7, 2024 · Daptomycin is a lipopeptide antimicrobial with activity against gram-positive organisms, including antimicrobial-resistant pathogens such as methicillin-resistant …

WebOct 15, 2024 · Background: Daptomycin-associated myopathy has been identified in 2%-14% of patients, and rhabdomyolysis is a known adverse effect. Although risk factors for daptomycin-associated myopathy are poorly defined, creatine phosphokinase (CPK) monitoring and temporary discontinuation of 3-hydroxy-3-methylglutaryl coenzyme A … WebMar 1, 2024 · Bloating or swelling of the face, arms, hands, lower legs, or feet fever tingling of the hands or feet unusual weight gain or loss Less common Agitation black, tarry stools bladder pain bloody or cloudy urine blurred vision chest pain, discomfort, or tightness chills confusion cough decreased awareness or responsiveness

WebMar 7, 2024 · Cubicin may cause serious side effects including: hives, difficulty breathing, swelling of your face, lips, tongue, or throat, severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose), … WebNov 23, 2024 · Daptomycin must be mixed with a liquid (diluent) before using it. Prepare your injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine. You may need frequent blood and urine tests. daptomycin may cause false results with certain medical tests.

WebMar 21, 2024 · Daptomycin may cause a kidney problem called tubulointerstitial nephritis. Check with your doctor right away if you have a bloody or cloudy urine, fever, skin rash, …

WebDaptomycin is given parenterally once a day. Over 90% is bound to serum protein. Dosing is adjusted for renal failure. Because daptomycin can cause reversible skeletal myopathy, patients should be monitored for muscle pain or weakness, and serum creatine kinase levels should be checked weekly. NOTE: This is the Professional Version. earthcam mammys kitchen mertle beach s.cWebDaptomycin: Temporarily suspend simvastatin: Grapefruit juice: Avoid grapefruit juice ... Simvastatin occasionally causes myopathy manifested as muscle pain, tenderness or weakness with creatine kinase (CK) above ten times the upper limit of normal (ULN). Myopathy sometimes takes the form of rhabdomyolysis with or without acute renal failure … cte of stainlessWebClinically relevant plasma concentrations of daptomycin reported to cause a significant concentration-dependent false prolongation of prothrombin time (PT) and elevation of International... earthcam little italy new yorkWebFocal fibrosing myopathies: Due to injections of drugs Selumetinib Valproate Mitochondrial disorders (MELAS): Induces myopathy & encephalopathy CPT-2 deficiency: Precipitates … cte of tantalum cte of urethaneWebRhabdomyolysis is a known possible complication associated with daptomycin therapy. However, previous findings were predominantly in phase 1 and 2 trials, and the effects … cte of ultemWebMitochondrial myopathy is caused by a defect in the mitochondria, which are the energy-producing part of cells. These conditions have muscle weakness, but also a variety of … cte of tungsten