Cisplatin hearing loss thesis

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August undefined, 2024

WebApr 1, 2011 · As has proven to be the case with noise-induced hearing loss and age-related hearing loss, oxidative stress has a key role in cisplatin ototoxicity. Additionally, like with noise and aging, apoptotic cell death has been identified as the primary mode of cell death in cochleae exposed to cisplatin. Web• Investigating molecular mechanisms underlying cisplatin and noise-induced hearing loss • Determining the role of transplatin as an …

Sodium thiosulfate for prevention of cisplatin-induced hearing loss ...

WebThe incidence of ototoxicity induced by cisplatin ranges from 20% to 70%, and it usually manifests as a progressive, bilateral and irreversible hearing loss. Although the etiology … WebBackground: Sensorineural hearing loss is a well-known side effect of cisplatin (CDDP). There is limited research on the effect of dosing, infusion times, and schedules of cisplatin administration and their impact on hearing loss. Methods: A retrospective review of 993 pediatric patients’ medical and audiological dictionary diabetes

Cisplatin ototoxicity: Examination of the impact of dosing, …

WebMay 19, 2024 · Cisplatin may cause hearing loss as a side effect. In the average-risk medulloblastoma patients, this trial tests whether the addition of sodium thiosulfate (STS) to standard of care chemotherapy and radiation therapy reduces hearing loss. Previous studies with STS have shown that it may help reduce or prevent hearing loss caused by … WebJun 21, 2024 · Hearing loss of grade 1 or higher occurred in 18 of 55 children (33%) in the cisplatin–sodium thiosulfate group, as compared with 29 of 46 (63%) in the cisplatin-alone group, indicating a 48% ... WebHearing loss induced by cisplatin or aminoglycosides is generally bilateral and begins at high frequencies, extend-ing to lower frequencies with prolonged treatment. … dictionary dewey decimal

Cisplatin and hearing loss - See why it causes hearing loss - Hear …

Cisplatin-induced ototoxicity: The current state of …

WebAug 31, 2016 · Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively impacting further on a patient’s quality of life. It is paramount for health care practitioners managing such patients to be aware of cisplatin’s ototoxic … WebCISPLATIN-INDUCED HEARING LOSS IN CHOP KO MICE 2 Abstract Cisplatin is a chemotherapeutic drug that causes hearing loss, and the mechanisms of its ototoxicity … dictionary devotionWebMar 26, 2024 · The severity of cisplatin-related ototoxicity is associated with age and the cumulative dose received: the younger the child and the higher the total dose, the more severe the hearing loss may be. The spectrum of hearing loss varies from mild to moderate high tone hearing loss, to profound loss across the hearing range and … dictionaryd fizbans treasury of dragons

"WebFeb 12, 2024 · More information: Diana J Moke et al. Prevalence and risk factors for cisplatin-induced hearing loss in children, adolescents, and young adults: a multi-institutional North American cohort study ... " - Cisplatin hearing loss thesis

Cisplatin hearing loss thesis

Cisplatin-induced ototoxicity: Updates on molecular …

WebCisplatin may cause serious hearing problems, especially in children. Hearing loss may be permanent in some cases. Your doctor will order tests to monitor your hearing before and during your treatment. Tell your doctor and pharmacist if you have ever had radiation therapy to your head. Tell your doctor and pharmacist if you are taking ... WebJul 3, 2024 · Cisplatin-induced hearing loss is associated not only with dosage, but also with the administration protocol. Whether used in single high dose or multiple low dose, …

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WebAug 25, 2024 · Platinum containing chemotherapeutic agents are associated with cochleotoxicity, characterized by high frequency hearing loss. Cisplatin and related … WebMar 29, 2024 · This hearing disorder results from temporary or permanent inner ear dysfunction, typically causing bilateral high-frequency sensorineural hearing loss that progresses to lower frequencies with continued exposure. 3 The risk of permanent bilateral sensorineural hearing loss and tinnitus can occur both during treatment and long-term …

WebFeb 11, 2024 · Cisplatin is a highly effective chemotherapeutic drug used against a wide range of childhood and adult cancers, but cisplatin … WebSep 4, 2024 · Scientists have found out why Cisplatin causes hearing loss. Cisplatin is a powerful drug used in some chemotherapy treatments to treat many forms of cancer. Cisplatin and similar platinum-based drugs are prescribed for an estimated 10 to 20 percent of all cancer patients.

WebJan 1, 2024 · Atorvastatin use significantly reduces the odds of a clinically meaningful cisplatin-induced hearing loss. An analysis of the incidence of a CTCAE-defined hearing loss due to cisplatin therapy in the full cohort and key subgroups is shown. For the full cohort and the subject subgroups, the difference in the incidence (% of ears) and 95% CI … WebCISPLATIN-INDUCED OTOTOXICITY: THE CURRENT STATE OF OTOTOXICITY MONITORING IN NEW ZEALAND _____ A thesis submitted in partial fulfilment of the …

WebNoise-induced hearing loss (NIHL) is a complex disease which might be caused by interactions between environmental and genetic factors. Noise is the best-known and one of the most studied environmental factors causing hearing loss.

WebNov 29, 2024 · Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): A multicentre, randomised, controlled, open-label, phase 3 ... city college programsWebCisplatin can cause irreversible hearing loss initially detectable as impairment of high-frequency hearing with progression to lower frequencies. Many patients receiving cisplatin are too ill to tolerate lengthy audiometric testing. Therefore, a rapid and sensitive high-frequency monitoring strategy … city college pre medWebCisplatin-Induced Hearing Loss Childhood Cancer Hearing Loss Patient Focused Drug Development (PFDD) Meeting The pediatric patient population with chemotherapy … city college rate my professorWebJan 25, 2024 · More than half of patients treated with cisplatin-based chemotherapy develop hearing loss or tinnitus, which can be devastating, say researchers who urge … dictionary dialectic dictionary dialogueWebJan 26, 2024 · A New Approach to Researching Cisplatin-Induced Hearing Loss. The new study differs from previous research because it is a comprehensive look at the pharmacokinetics, or concentration, of the … city college psychology coursesWebApr 17, 2024 · For patients treated with the chemotherapeutic drug cisplatin, one common consequence of treatment is permanent hearing loss. Reported rates of cisplatin … city college psychology major